Category Archives: Knowledge & Training

Free Bioengineering Symposium at UNH on May 10

By | April 27, 2017

The 2017 University of New Hampshire Bioengineering Symposium on Wednesday, May 10 is a full-day event featuring several talks by invited speakers in key areas that are at the forefront of cutting-edge research worldwide and broadly represent the field of bioengineering. Topics include: Engineering Total Joint Replacements; In Vitro Models of Tissue Morphogenesis and Disease… Read More »

ISA Food and Pharmaceutical Industry Division 4th Annual Symposium Arrives in Framingham May 16-17

By | April 10, 2017

Competitive forces, changing marketplace dynamics, and regulatory pressures are generating greater demand and need for new and more effective automation technologies in the pharmaceutical and food industries. More than ever before, manufacturing companies are seeking solutions and methodologies that increase quality, safety, reliability, profitability, cost control and production throughput. On May 16-17 at the Sheraton… Read More »

AiChE Boston Presents “Fundamentals of Bulk Solids Handling” on Saturday, April 29

By | April 5, 2017

If you work with powders or other bulk solids and are interested in learning how to design bulk solid handling systems, this workshop is for you! Systems for handling powders and other bulk solids are often improperly designed, leading to: Erratic flow, no flow or limited throughputs Poor product quality and excessive downtime Customer complaints Safety issues including… Read More »

Single Use Manufacturing & the Impact on Process, Facility Design & Procurement

By | April 3, 2017

Single use technology opens up a world of possibilities never considered before for biotech/pharma manufacturing but also brings with it a host of new challenges. As companies move from simple application of single use systems like bags (for buffer storage) to more complex single use systems and even entire single use facilities, the potential impact… Read More »

Is Continuous Manufacturing in Your Future?

By | March 29, 2017

Is continuous manufacturing in your future? After all, the technology to enable continuous manufacturing of biopharmaceuticals is rapidly being developed. After attending the Chapter’s educational program at Takeda Pharmaceuticals on March 16, my conclusion is that continuous manufacturing is definitely in our future but, as with past transformations in technology, adoption by industry will be… Read More »

Continuous Biopharmaceutical Manufacturing – Possible, Improbable, or Unavoidable?

By | March 6, 2017

I don’t remember a lot of effort going into learning about batch processing in my chemical engineering studies.  Continuous processing was the norm in refineries and many chemical plants.  Steady state equated to even quality, and output could be tuned for maximum efficiency.  The world revolved around a well understood material balance.  Batch was for… Read More »

Transforming Downstream Processing through Multi-Column Chromatography

By | March 6, 2017

The call for implementing continuous processing in the manufacturing of bio-pharmaceuticals requires re-thinking of process chromatography and its equipment design. Proof-of-concepts of innovative multi-column continuous processes were introduced by the industry, which verified improvements in resin utilization and increased productivity [1]. Now, these concepts are transferred and verified at the pilot and production scale. First… Read More »

USP Updates Informational Chapter <1231> on Pharmaceutical Water

By | March 2, 2017

For those who have an interest in pharmaceutical waters, the recently released USP 39 Supplement 2 includes an updated Informational Chapter <1231>. This new and improved chapter has been rewritten and reorganized including a new table of contents, added hyperlinks for contemporization and ease of use, clear and concise technical explanations, and additional material including… Read More »

Pharmaceutical Water and Steam: Important Updates on the State-of-the-Art

By | February 3, 2017

The pharma and biotech industries spend millions of dollars annually in costly investigations into alert, action, and out of specification excursions related to the critical utilities of water and steam. These expenditures could be greatly minimized if the issues and challenges related to sampling were clearly understood. To address this knowledge gap, ISPE has introduced… Read More »